Dexedrine Side Effects

Important Information For Dexedrine Users

Common Dexedrine side effects include decreased appetite, nausea, irritability, and insomnia. However, they only occur in a small percentage of Dexedrine users. 

These side effects tend to be common among all stimulant-derived medications.

What Is Dexedrine?

Dexedrine is used to treat Attention Deficit Hyperactivity Disorder, commonly referred to as ADD or ADHD. Dexedrine works by interacting with the chemicals in the brain that contribute to impulse control and hyperactivity.

The "Rebound" Phenomenon

Rebound is the phenomenon where some experience irritability or depression for an hour as the drug wears off. One can avoid rebound by spacing the doses closer together, giving a smaller dose after the final larger dose, or by switching to a longer acting stimulant.

Recently several new long-acting stimulant preparations have been released. Although the long-acting compounds often have less rebound, it may still occur in susceptible individuals.


Ever consumed too much caffeine? Like all stimulants, Dexedrine produces the jitters and the shakes. To avoid this try eliminating all caffeine and other stimulants. A small dose of a beta-blocker (a type of blood pressure medication) can block tremors, shakes and jitters. Be sure to eat regular meals and ingest some food.

Appetite Decrease

A decreased appetite is a common effect of ADHD medications. It can be range from mild to severe, but if it continues to be problematic, talk to your doctor. For example, medication times and dosages can be adjusted to help prevent appetite loss. Often a large breakfast, small lunch and large supper can do the trick. Or a late evening snack can also help.

Stomach Upset: Nausea

Another common side effect of any stimulant. Take the medication with meals or eat smaller, more frequent meals.

Sleep Disturbances

dexedrine side effects

Sometimes sleep disturbances are due to ADHD, not the effects of Dexedrine. Therefore, it is a good idea to take a sleep history before starting taking any stimulants. If sleep disturbances are due to the medication, there are several options such as adjusting dosages and medication times.

Irritable Mood

Irritability and mood changes may be due to ADHD, but it can also result from ADHD medications such as Dexedrine. To combat this side effect, the Dexedrine dosage may be altered or another ADHD medication could be substituted.

Dexedrine Side Effects: Safety Tips

Only take Dexedrine as prescribed under the direct supervision of your doctor. Do not alter doses, and follow the prescription instructions precisely. Report any adverse or unusual side effects to your doctor. If you experience any severe reactions, seek immediate medical attention.

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