Cymbalta Dosage Guide

Finding the most effective Cymbalta dosage usually depends on individual factors such as age, medical condition, sex, overall physical condition, mental health history, and other medications one may be taking.

It is important to understand that every individual is different and there is often no magic dosage for everyone. There are, however, some basic starting dosage recommendations.

What Is Cymbalta?

Cymbalta (Duloxetine) is an antidepressant that is also used to treat anxiety disorders, and pain caused by diabetes and Fibromyalgia.

It belongs in the class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs). These drugs work by by interacting with the serotonin levels in the brain.

General Cymbalta Dosage Guidelines For Different Conditions

These are general dosage guidelines because one's actual dose will vary on a case-by-case basis.

For example, for adults suffering from depression, a common initial dose is 20 mg or 30 mg twice daily. A common maintenance dose is between 60 mg and 120 mg daily.

Doses typically do not exceed 120 mg daily based on clinical trials that indicate that doses greater than 60 mg daily often do not yield additional benefits.

For anxiety, the recommended starting dose is typically 60 mg once daily. Doses rarely exceed 120 mg daily as research indicates that doses greater than 60 mg daily confer no additional benefits.

Similarly, a typical starting Cymbalta dose for pain related to diabetes and Fibromyalgia is 60 mg per day.


Do not mix this medication with alcohol.

cymbalta dosage

See this detailed warning about mixing antidepressants and alcohol. Both alcohol and antidepressants such as Cymbalta can adversely affect or hinder one's ability to operate heavy machinery such as driving an automobile. 

Also, if you are pregnant or thinking about becoming pregnant while taking this medication, notify your doctor. Caution should be heeded when taking antidepressants during pregnancy. See antidepressants and pregnancy.

Finally, remember to follow the prescription instructions exactly. Only take this medication as advised under the supervision of your prescribing medical professional. Do not take a dose of Cymbalta that exceeds your prescription recommendations.

Also, you should never take anyone else's prescription Cymbalta. You should only take prescription medications that were prescribed for you.

If you experience any adverse reactions, report them immediate to your doctor. If your reaction is severe, seek emergency medical attention at your nearest hospital. Most importantly, you should seek immediate medical attention if you are experiencing suicidal thoughts or behaviors while taking Cymbalta.

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